A total of 133 women with rheumatoid arthritis were included in this randomized, blinded, prospective, 16-week controlled trial. The subjects were randomized into 3 groups:
- water-based aerobic exercises – 33 women
- land-based aerobic exercises – 33 women
- Control – 34 women
Muscle strength was measured using an isokinetic dynamometer. Disease activity (DAS-28) and functional ability (health assessment questionnaire) were measured by an expert rheumatologist. Total body densitometry was used to assess body composition. The intervention was performed 3 times per week, and all groups were evaluated at baseline and after 8 and 16 weeks. Compliance, concomitant medications, and adverse events were recorded. The data were analyzed by intention to treat. P < 0.05 was set as significant.